Nephrology & Urology Xagena

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Intestinal metaplasia of the bladder: potential malignancy need to be taken into consideration

Intestinal metaplasia of the bladder is an uncommon glandular proliferation. Researchers have examined a large series of intestinal metaplasia for the clinicopathological features and discuss the significance of this lesion.

All cases of intestinal metaplasia diagnosed at Rui Jin Hospital Lu Wan Branch, Shanghai Jiaotong University ( Shanghai, China ) between 1990 and 2014 were retrospectively reviewed.
Patients with a history of urothelial carcinoma or concurrent adenocarcinoma were excluded.

Researchers have identified 89 patients with intestinal metaplasia during this period. Sixty seven were men and 22 were women. Mean age at diagnosis was 57 years ( range 23-81 ). Common presenting complaints included haematuria ( 73 cases ), mucosuria ( 13 cases ), and irritative voiding symptoms ( 7 cases ).
The majority of intestinal metaplasias located on or near the trigone ( 67 cases ).

Eighty-two patients underwent transurethral resection of their lesions. Partial cystectomy was performed in the remaining seven patients.

The mean follow-up of 78 patients was 105 months ( range 6-255 ).

One case of bladder adenocarcinoma was indentified 6 months later. The initial histologic findings had revealed intestinal metaplasia with severe dysplasia.

Four patients presented recurrence during the follow-up, and this occurred 9, 13, 17 and 24 months after the surgery.

In conclusion, although intestinal metaplasia can be treated effectively by transurethral resection in most cases, its potential malignancy need to be taken into consideration after the evidence of recurrences and its association with bladder adenocarcinoma.
Therefore, it is necessary to perform close surveillance following the surgery, particularly in patients with dysplastic changes. ( Xagena )

Xin Z el al, BMC Urol 2016;16:24. doi: 10.1186/s12894-016-0142-x.