Urology Xagena

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Men with hypertension are more likely to have severe lower urinary tract symptoms and large prostate volume

Patients with lower urinary tract symptoms ( LUTS ) have a higher prevalence of cardiovascular disease. Researchers have evaluated the correlation between LUTS and cardiovascular risk factors in men presenting with benign prostatic hyperplasia ( BPH ).

The medical records of 295 men with transurethral resection of the prostate for the treatment of benign prostatic hyperplasia and lower urinary tract symptoms were retrospectively reviewed.

Risk factors for cardiovascular disease included: hypertension, diabetes mellitus, smoking, and dyslipidemia.

The severity of lower urinary tract symptoms measured by the International Prostatic Symptom Score ( IPSS ), prostate volume, prostate specific antigen ( PSA ), maximal urinary flow rate ( Qmax ), and postvoid residual urine ( PVR ) in subjects with or without cardiovascular risk factors were compared.

IPSS-total ( 22.9 ± 7.8 vs. 21.2 ± 7.3, P = 0.01 ) and obstructive symptom score ( 13.3 ± 5.2 vs 11.9 ± 4.7, P = 0.01 ) were significantly different between men with hypertension and without cardiovascular risk factors.

There was no significant difference of variables between subjects with diabetes mellitus, smoking or dyslipidemia and without cardiovascular risk factors.

In the Pearson correlation, the systolic and diastolic blood pressure were related with prostate volume ( r = 0.138, P = 0.040; r = 0.163, P = 0.020 ), IPSS-total ( r = 0.139, P = 0.043; r = 0.138, P = 0.043 ), and an obstructive symptom score ( r = 0.168, P = 0.014; r = 0.143, P = 0.037 ), respectively.

In conslusions, men with hypertension are more likely to have a higher IPSS and large prostate volume than men without hypertension.
This finding implicates a pathophysiological association between hypertension and lower urinary tract symptoms, and the need to manage comorbid symptoms simultaneously. ( Xagena )

Hwang EC et al, Low Urin Tract Symptoms 2015;7:32-36