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ADXS-PSA, an attenuated Listeria monocytogenes-based immunotherapy that targets prostate-specific antigen ( PSA ), is designed to generate antigen-specific T cell effectors that kill tumor cells. Pu ...


Anti-PD1 treatment with Pembrolizumab ( Keytruda ) is a promising treatment strategy in many solid tumors. Researchers have reported clinical outcomes of adding Pembrolizumab to men with metastatic ...


Cabozantinib ( Cabometyx ) has shown robust clinical activity in advanced clear cell renal cell carcinoma ( RCC ). Non-clear cell renal cell carcinoma ( nccRCC ), a heterogeneous mix of diseases, ha ...


Radium-223 dichloride ( Ra-233; Xofigo ), a bone targeting alpha radiopharmaceutical, and Enzalutamide ( Xtandi ), are approved for metastatic castration refractory prostate cancer ( mCRPC ). Per SW ...


The phase 3 PROSPER trial has showed a statistically significant improvement in metastasis-free survival ( MFS ) with Enzalutamide ( Xtandi; n = 933 ) versus placebo ( n = 468 ) in asymptomatic men wi ...


Data, presented at 2018 American Society of Clinical Oncology ( ASCO ) Annual Meeting, showed clinical improvement in median radiologic progression-free survival ( rPFS ) with Olaparib ( Lynparza ) in ...


Although immune checkpoint inhibitors ( ICI ) have improved outcomes in some patients with Platinum-resistant metastatic urothelial carcinoma ( mUC ), many patients ( eg, patients with TCGA luminal 1 ...


New findings were presented at the American Society of Clinical Oncology Genitourinary Cancers Symposium ( ASCO GU ) in San Francisco, and were simultaneously published in The New England Journal of M ...


Over the past decade, several systemic agents as Docetaxel, Cabazitaxel, Sipuleucel-T, Abiraterone and Enzalutamide have improved overall survival ( OS ) in metastatic prostate cancer ( mPCa ) patient ...


Data from the pivotal phase 3 LATITUDE clinical trial showed Abiraterone acetate ( Zytiga ) plus Prednisone, in combination with androgen deprivation therapy ( ADT ), demonstrated a significant improv ...


Autophagy is a conserved evolutionary process that allows cells to maintain macromolecular synthesis and energy homeostasis during starvation and stressful conditions. Researchers prospectively ev ...


Shorter sleep duration was associated with increased risk of death from prostate cancer in men under the age of 65. There is growing interest in determining the potential health effects of factors ...


A new analysis of patients who have undergone treatment for prostate cancer shows a connection between androgen deprivation therapy ( ADT ), a testosterone-lowering therapy and a common treatment for ...


About half of all women will experience urinary tract infections ( UTIs ) in their lifetimes, and despite treatment, about a quarter will develop recurrent infections within six months of initial infe ...


Renal cell carcinoma ( RCC ) accounts for approximately 330,000 cases diagnosed each year and 140,000 deaths worldwide. Most cases are localized; however, one-third of patients present with an advanc ...